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For patients whose clinical situation requires moderate rather than maximal weight loss, such as those with early-stage metabolic dysfunction where 10-12% weight loss is sufficient to normalize metabolic parameters, orforglipron's efficacy profile may be adequate and its oral convenience advantageous

Potential pancreatitis risk : As with other GLP-1-based therapies, there is a theoretical concern regarding pancreatitis, though causality has not been firmly established in trials to date

Another consequence of a compensatory increased in local IGF-I activity is the finding of normal childhood and pubertal linear growth despite endocrine IGF-I deficiency in type 1 diabetes (86)