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Note that unlike other water-soluble vitamins, B12 can be stored in the liver for a long time, so it might be years before B12 deficiency symptoms start appearing

Mitochondrial Dysregulation and Oxidative Stress in Patients with Chronic Kidney Disease

N., Zhou, F

Autophagy 17(4):872887 Houghton CA, Fassett RG, Coombes JS (2016) Sulforaphane and other nutrigenomic Nrf2 activators: can the clinicians expectation be matched by the reality