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These promising results suggest AST could serve as an effective adjunct in AD therapy, though further clinical studies are needed to establish its long-term benefits

2,6 Although the majority of patients experience mild adverse reactions, such as hepatitis, cholestasis or asymptomatic liver enzyme elevation, APAP hepatotoxicity is generally estimated to account for approximately 48% of acute liver failure diagnoses

For quantitative real-time polymerase chain reaction (qPCR), samples were assayed in duplicate using the SsoAdvanced Universal SYBR Green Supermix (Bio-Rad, Hercules, CA)