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In our study, we also found large intracellular A aggregates localized in the cytoplasm in old age 3xTg-AD hippocampal neurons, as well as in the brains of these mice [38]

However, NDI1 does not contribute to the maintenance of mitochondrial morphology, ATP production, and mitochondrial membrane potential

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Other widely employed approaches include the strategic incorporation of unnatural amino acids, backbone conjugation, or cyclization techniques to modulate protein activity, enabling the design of synthetic variants with improved efficiency 3,4,5,6