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Theriogenology 186, 168174

755 Mechanistically, SSAT1 overexpression increases ALOX15 expression and decreases the expression levels of GPX4 and SLC7A11 in primary cortical neurons, suggesting that SSAT1/ALOX15 axis activation may aggravate brain I/R injury by triggering ferroptosis in neurons

Fe + from heme and non-heme sources is transported to the basal surface of enterocytes, reoxidized to Fe + by ferroferrin (HEPH), exported via the export protein ferroportin (FPN) (51), and then loaded onto the circulating iron transporter transferrin (TF) for systemic delivery

And it also possesses a particular regulatory mechanism of its occurrence