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In a cohort study of 80 male patients with alcoholic cirrhosis and 70 healthy male non-alcoholic controls, MDA levels, a known marker of lipid peroxidation, were significantly higher in those with alcoholic cirrhosis.Additionally, a negative correlation was found between MDA levels and the activities of antioxidant enzymes such as superoxide dismutase (SOD), GPx, and glutathione (GSH), indicating heightened oxidative stress and impaired antioxidant defense in ALD patients (79) ( Figure 1 )

This study shows that, in addition to its enzymatic activity, PFKFB4 can also modulate metabolism by regulating gene transcription

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