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Our data also suggest that Sp, in combination increases the therapeutic potency of L-DOPA by mitigating its chronic toxicity

Invest Ophthalmol Vis Sci 53 : 35723583

esculetin, have been shown to regulate activation of JNK and AMPK in liver injury and to exhibit hepatoprotective effects

Mitophagy is critical for cellular homeostasis, as insufficient mitophagy can lead to the release of mitochondrial components, such as mtDNA, into the cytoplasm, triggering inflammation [29]