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We reduced the dimensionality of the chromatin accessibility data by latent semantic indexing, by first normalizing using the term frequency-inverse document frequency (TF-IDF) normalization method, followed by a singular value decomposition using all peak features implemented in Signac

For this reason, the decision to use it should be individualised and, if there is pre-existing pathology, under supervision

The change in UPDRS score from baseline to final visit was used as the primary outcome to assess improvements following supplementation

Compared to SD-fed control, HAGE intake for 12 weeks induced intestinal permeabilization, as evidenced by an in vivo FITC-Dextran assay (Fig