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Cigarette smoke contains more than 5000 chemicals that are toxic to our body, including our immune system 37 : for example, they increase reactive oxygen species production and modulate immune functions 7 , while nicotine, which is abundant in CSE, suppresses T cells by inducing anergy and apoptosis 38,39

Step 1: systematic review approach to literature search and data extraction Informed by the systematic review approach we took for the GBD 2019 (ref

In one such establishment, the owner seems unbothered by the transgression

They are also required to verify the age and ID of customers, who must also be 21 or older