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BPC-157 Before and After for Gut Health: A Different Timeline Entirely Gut indications follow a fundamentally different before and after trajectory than musculoskeletal indications, and patients who come to Perfect B with both gut and injury concerns are often surprised by how much faster the gut improvements arrive

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

Glucose-stimulated insulin secretion (GSIS) in INS-1E cells Insulin secretion assays in INS-1E cells were conducted as described earlier 7,42

Primary endpoints were (1) collection of adverse events and laboratory parameters