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Treatment continued until the occurrence of radiologic progression, as defined by mRECIST, 44 symptomatic progression, unacceptable toxicity, or death

This increase in DNA methylation levels may be associated with transcriptional regulation, potentially leading to a reduction in the expression of these genes

Thereby, we suggest that this vascular recovery might serve as a common defensive principle [5,6,66,71,72,73,74,75,76,77,78,79,80,81,82]

Approximately 90% of the body's serotonin is produced in the gastrointestinal tract, with fewer quantities found in the brainstem, especially in the raphe nuclei, as well as in the skin, lungs, and taste receptor cells [86]