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However, avoid taking it with high-fat meals, as this might reduce absorption

Those cases, in which antioxidant therapy has been shown to have a positive effect, will also be discussed

Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of target genes involved in glutathione synthesis, iron sequestration, and detoxification of lipid peroxides ( In the cancer context, aberrant activation of the Nrf2 is frequently observed and contributes to tumor progression by counteracting lipid peroxidation and ferroptosis

In addition, symptoms extend far beyond the digestive concerns that are most commonly discussed with respect to celiac disease and gluten sensitivity