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Nat Rev Drug Discov 12: 931947 Goswami MT, Chen G, Chakravarthi BV, Pathi SS, Anand SK, Carskadon SL, Giordano TJ, Chinnaiyan AM, Thomas DG, Palanisamy N, Beer DG, Varambally S (2015) Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer

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This pH-sensitive system demonstrated enhanced drug release in acidic environments, with superior toxicity to HepG2 liver cancer cells compared to free aspirin