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One study revealed that mice with system Xc knockdown showed rapidly advancing retinal aging, increased retinal strain, elevated ROS levels, and compromised mitochondrial activity, providing a beneficial framework for investigating retinal aging and AMD (224)

LINC01127, in collaboration with Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), activates the JNK pathway to enhance the communication with the NF-B pathway, culminating in the augmentation of the migratory capabilities and the self-renewal rate of glioma stem cells (GSCs) [151]