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PLA2, a BV component, contains a forkhead box P3 (Foxp3), + CD4, + CD25, + Treg cell that protects against radiotherapy-induced extensive pulmonary inflammation (Hossen et al., 2017b)

However, the predominance of in vitro and acute in vivo models highlights the need for systematic evaluation of long-term safety, biodistribution, and translational relevance in clinically relevant neurological settings [151153]