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Class I ferroptosis inducers (FINs), including sorafenib, sulfasalazine, erastin, and its analog imidazole ketone erastin, inhibit system Xc-, disturb the synthesis of GSH, and subsequently deplete GSH to suppress the GPX4 enzyme activity

Crit Rev Food Sci Nutr 63(26):84038427 Rahimi P, Mesbah-Namin SA, Ostadrahimi A, Abedimanesh S, Separham A, Jafarabadi MA (2019) Effects of betalains on atherogenic risk factors in patients with atherosclerotic cardiovascular disease

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Because IL-10 is an essential cytokine, understanding how metabolism is controlled in parallel to suppression of inflammatory cytokines and chemokines may have valuable clues for translation approaches in inflammatory bowel disease and other chronic conditions where there is not enough IL-10 or IL-10 signaling