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Mechanism of IL-1 modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation

Recent studies showed that introduction of sugar moieties to heavily carborane-loaded hY 1 R selective analogs can enhance solubility and thereby enable the boron conjugation of up to 80 boron atoms (Worm et al., 2019) (Figure 11)

The same molecule as Ozempic/Wegovy The combination approach has the advantage of using two individually optimized and validated components