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Mannose inhibits PKM2 lactylation to induce pyroptosis in bladder cancer and activate antitumor immune responses

By running two side-by-sides studies in which only the pH varies (pH 7.4 or pH 9, respectively), a factor can be calculated which can be used in future experiments run at pH 9 to calculate the equivalent reaction kinetics of an experiment performed at pH 7.4

At the same time, the pro-IL-1 and pro-IL-18 cleaved by CASPASE1 were exchanged into mature IL-1 and IL-18 and released through the aforementioned pores to trigger further inflammatory reactions [2, 30, 31]