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Mixing drugs at high doses is probably going to give you a higher likelihood of having an adverse effect, than just having one drug at a high concentration, Sodergren says

In multivariate MR, the SNPs utilized as IVs must satisfy the following conditions: 1) they should be associated with all exposure factors in the model, 2) they should not impact the outcome variables through alternative pathways, and 3) the number of SNPs should exceed the number of exposure factors