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Significantly, a compound denoted as melatonin-trientine, covalently synthesized with melatonin and the metal ion chelator trientine, demonstrated the capacity to elevate the expression of IDE in a murine AD model, and decreased A deposition and neuronal degeneration in the brains of the APP/Presenilin 1 mice [65]

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Our data suggest that a protocol consisting of mitochondrial-targeted cofactors (co-enzyme Q10 and L-carnitine) plus amitriptyline (or possibly cyproheptadine in preschoolers) coupled with fasting avoidance and blood level monitoring is highly effective in the prevention of vomiting episodes

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