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What Happens to Your Body, When You Take a Puff of a Cigarette? Keck Medicine of USC This Is What Happens When You Smoke , Every puff exposes your body to thousands of chemicals, many of which are harmful., Your lungs become damaged over time, Your heart has to work harder, When you smoke, it's not just your health that is at risk. A smoker only inhales about 15% of the smoke from a cigarette the other 85% goes into the air Cigarette smoke causes breathing problems and cancer

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