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Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

Chronic hypercortisolism exposure has particularly significant damaging effects on the hippocampus, leading to neuronal dendritic atrophy, reduced synaptic density, and neurogenesis inhibition, resulting in an average 810% reduction in hippocampal volume in depression patients (Cryan et al., 2019)

Therefore, to try to understand whether GENUS could exert a neuroprotective effect decreasing ROS, lipid peroxidation, and iron accumulation, we analyzed the expression of glutathione peroxidase 4 (GPX4), which is the master regulator of ferroptosis by reduction of cytotoxic lipid peroxides 61

SchapiraAHCooperJMDexterDClarkJBJennerPMarsdenCD.Mitochondrial complex I deficiency in Parkinsons disease