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10.1016/j.ejmech.2018.08.034 57 RenJ.WangX.LiJ

Density plot showing decreased abundance of PS and increased abundance of PC-1 for primitive compared to committed phenotype(n = 96 patients)

Next, the sections were incubated with horseradish peroxidase-conjugated anti-rabbit antibodies (Alpha Diagnostic, San Antonio, TX, United States) for 20 min in a 37C incubator and then rinsed with PBS three times for 5 min each

Sertraline responders also show reductions in KYN/melatonin and 3-HK/melatonin ratios changes absent in non-responders [195] further supporting the notion that a shift in KP metabolite concentrations contributes to antidepressant efficacy