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Finally, epigenetic regulation via histone modification, such as acetylation of methylation at the NLRP3 promoter and DNA methylation, silences NLRP3 expression and further refines its transcriptional control, highlighting the intricate regulation of this critical inflammasome component [52]

In order to better tailor the next generation of Pt nanozymes, it may be necessary for us to perform appropriate surface modifications to improve the selectivity and stability of Pt nanozymes under physiological conditions, with the aim of reducing off-targeting with proteins or cellular components