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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

& Leib, D

Hantute-Ghesquier A, Haustrate A, Prevarskaya N

Thus, this early research suggests that huperzine A is indeed capable of crossing the blood-brain barrier , meaning that it is reasonable to believe that taking it results in it actually getting to the brain (where it could have some of the cognitive effects described in the previous sections of this post)