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4 Oxidative stress in gastric cancer 4.1 Gastric carcinogenesis Under oxidative stress, increased ROS in cells may harm tissues and trigger carcinogenesis, especially in the gastrointestinal system ( Figure 3 )

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The buildup of oxidized lipids containing polyunsaturated fatty acids (PUFAs) in cell membranes triggers ferroptosis (Fig

Although hepcidin primarily originates from hepatic sources, an in vitro study revealed that interferon- (IFN-) regulates hepcidin expression in AECs without significantly impacting iron transport in these cells or alveolar macrophages [107]